Low 2D:4D is associated with delayed age at menarche among women of Sikkim, India

Authors

DOI:

https://doi.org/10.18778/1898-6773.86.3.02

Keywords:

Menarche, 2D:4D, Reproductive pattern, prenatal hormone

Abstract

The index-finger and ring-finger ratio (2D:4D) is a potential biomarker that reflects prenatal hormonal exposure and thus has a long-term impact on reproductive health. The present study aims to determine the relationship between the 2D:4D (representing the prenatal hormonal environment, i.e., early androgen exposure) and early or delayed age at menarche among women in Sikkim, India. A total of one hundred nineteen Sherpa tribal women, ages 18–49, from the Soreng district of Sikkim, India, were included in the study using a stratified random sampling method. To calculate the 2D:4D ratio, the lengths of the index and ring fingers (2D and 4D) were measured using standard procedures. The category-wise mean comparison revealed that women with a more feminine 2D:4D ratio (in both left and right hand) had significantly earlier age at menarche (in years) compared to women with a more masculine 2D:4D ratio. The linear regression analysis revealed that the left 2D:4D was significantly related to menarche age. There is an association between the 2D:4D and menarche age, indicating a link between women’s reproduction patterns and the influence of the prenatal hormonal environment as an important factor in attaining an early or delayed menarcheal age.

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References

Benderlioglu Z, Nelson RJ. 2004. Digit length ratios predict reactive aggression in women, but not in men. Horm Behav 46:558–64. https://doi.org/10.1016/j.yhbeh.2004.06.004
View in Google Scholar

de Sanctis V, Soliman AT, Elsedfy H, Soliman N, Elalaily R, Di Maio S. 2017. Is the Second to Fourth Digit Ratio (2D:4D) a Biomarker of Sex-Steroids Activity?. Pediatr Endocrinol Rev 14(4):378–386. https://doi.org/10.17458/per.vol14.2017.SSE.SexSteroids
View in Google Scholar

Eresheim R, Schaufler S, Kirchengast S. 2020. Association patterns between 2D:4D ratio and age at menarche: the impact of methodology. Anthropol Rev 83(4): 377–386. https://doi.org/10.2478/anre-2020-0026
View in Google Scholar

Fink B, Manning JT, Neave N, Grammer K. 2004. Second to fourth digit ratio and facial asymmetry. Evol Hum Behav 25(4):125–132. https://doi.org/10.1016/S1090-5138(03)00084-9
View in Google Scholar

Goto R, Mascie-Taylor CG. 2007. Precision of measurement as a component of human variation. J Physiol Anthropol 26(2):253–256.
View in Google Scholar

Gooding DC, Chambers BH. 2018. Age of pubertal onset and 2nd to 4th digit ratios: Preliminary findings. Early Hum Dev 116:28–32. https://doi.org/10.1016/j.earlhumdev.2017.10.007
View in Google Scholar

Guldbrandsen K, Håkonsen LB, Ernst A, Toft G, Lyngsø J, Olsen J, Ramlau-Hansen CH. 2014. Age of menarche and time to pregnancy. Hum Reprod 29(9):2058–2064. https://doi.org/10.1093/humrep/deu153
View in Google Scholar

Helle S. 2010. Does second-to-fourth digit length ratio (2D:4D) predict age at menarche in women? Am J Hum Biol 22(3):418–20. https://doi.org/10.1002/ajhb.21000
View in Google Scholar

Helle S, Lilley T. 2008. Maternal 2nd to 4th digit ratio does not predict lifetime offspring sex ratio at birth. Am J Hum Biol 20:700–3. https://doi.org/10.1002/ajhb.20796
View in Google Scholar

Kalichman L, Batsevich V, Kobyliansky E. 2013. 2D:4D finger length ratio and reproductive indices in a Chuvashian population. Am J Hum Biol 25(5):617–621. https://doi.org/10.1002/ajhb.22420
View in Google Scholar

Kirchengast S, Dottolo E, Praxmarer E, Huber J. 2020. Low digit ratio (2D:4D) is associated with early natural menopause. Am J Hum Biol 32(3):e23374. https://doi.org/10.1002/ajhb.23374
View in Google Scholar

Klimek M, Galbarczyk A, Nenko I, Jasienska G. 2016. Women with more feminine digit ratio (2D:4D) have higher reproductive success. Am J Phys Anthropol 160(3):549–553. https://doi.org/10.1002/ajpa.22989
View in Google Scholar

Kowal M, Sorokowski P, Żelaźniewicz A, Nowak J, Orzechowski S, Żurek G, Żurek A, Juszkiewicz A, Wojtycka L, Sieniuć W, Poniatowska M, Tarnowska K, Kowalska K, Drabik K, Łukaszek P, Krawczyk K, Stefaniak T, Danek N. 2020. No relationship between the digit ratios (2D:4D) and salivary testosterone change: Study on men under an acute exercise. Sci Rep 10:10068. https://doi.org/10.1038/s41598-020-66915-9
View in Google Scholar

Li T, Meng Y, Yao R, Han H, Wu L, Zhou Y, Li Z, Zhang Y, Fu L. 2019. The associations between left-hand digit ratio (2D:4D) and puberty characteristics among Chinese girls. Early Hum Dev 130(3):22–26. https://doi.org/10.1016/j.earlhumdev.2019.01.007
View in Google Scholar

Luijken J, van der Schouw YT, Mensink D, Onland-Moret NC. 2017. Association between age at menarche and cardiovascular disease: A systematic review on risk and potential mechanisms. Maturitas 104(10):96–116. https://doi.org/10.1016/j.maturitas.2017.07.009
View in Google Scholar

Mackus M, de Kruijff D, Otten LS, Kraneveld AD, Garssen J, Verster JC. 2017. The 2D:4D Digit Ratio as a Biomarker for Autism Spectrum Disorder. Autism Res Treat 2017:1048302. https://doi.org/10.1155/2017/1048302
View in Google Scholar

Manning JT, Barley L, Walton J, Lewis-Jones DI, Trivers RL, Singh D, Thornhill R, Rohde P, Bereczkei T, Henzi P, Soler M, Szwed A. 2000. The 2nd:4th digit ratio, sexual dimorphism, population differences, and reproductive success. Evidence for sexually antagonistic genes?. Evol Hum Behav 21(3):163–183. https://doi.org/10.1016/s1090-5138(00)00029-5
View in Google Scholar

Manning JT, Callow M, Bundred PE. 2003. Finger and toe ratios in humans and mice: implications for the aetiology of diseases influenced by HOX genes. Med Hypotheses 60(3):340–343. https://doi.org/10.1016/s0306-9877(02)00400-0
View in Google Scholar

Manning JT, Fink B. 2008. Digit Ratio (2D:4D), dominance, reproductive success, asymmetry, and sociosexuality in the BBC Internet study. Am J Hum Biol 20(4):451–461. https://doi.org/10.1002/ajhb.20767
View in Google Scholar

Manning JT, Fink B. 2011. Is low digit ratio linked with late menarche? Evidence from the BBC internet study. Am J Hum Biol 23(4):527–533. https://doi.org/10.1002/ajhb.21186
View in Google Scholar

Manning JT, Kilduff LP, Trivers R. 2013. Digit ratio (2D:4D) in Klinefelter’s syndrome. Andrology 1(1):94–9. https://doi.org/10.1111/j.2047-2927.2012.00013.x
View in Google Scholar

Manning JT, Scutt D, Wilson J, Lewis–Jones DI. 1998. The ratio of 2nd to 4th digit length: a predictor of sperm numbers and concentrations of testosterone, luteinizing hormone and oestrogen. Hum Reprod 13(11):3000–3004. https://doi.org/10.1093/humrep/13.11.3000
View in Google Scholar

Manning JT, Taylor RP. 2001. Second to fourth digit ratio and male ability in sport: implications for sexual selection in humans. Evol Hum Behav 22(1):61–69. https://doi.org/10.1016/s1090-5138(00)00063-5
View in Google Scholar

Manning JT. 2002. Digit ratio: a pointer to fertility, behaviour, and health. New Jersey: Rutgers University Press.
View in Google Scholar

Matchock RL. 2008. Low digit ratio (2D:4D) is associated with delayed menarche. Am J Hum Biol 20(4):487–489. https://doi.org/10.1002/ajhb.20763
View in Google Scholar

McIntyre MH. 2006. The use of digit ratios as markers for perinatal androgen action. Reprod Biol Endocrinol 4:10. https://doi.org/10.1186/1477-7827-4-10
View in Google Scholar

Muller DC, Baglietto L, Manning JT, McLean C, Hopper JL, English DR, Giles GG, Severi G. 2012. Second to fourth digit ratio (2D:4D), breast cancer risk factors, and breast cancer risk: a prospective cohort study. Br J Cancer 107(9):1631–1636. https://doi.org/10.1038/bjc.2012.418
View in Google Scholar

Oberg AS, Villamor E. 2012. Low digit ratio predicts early age at menarche in Colombian schoolgirls. Paediatr Perinat Epidemiol 26(5):448–55. https://doi.org/10.1111/j.1365-3016.2012.01310.x
View in Google Scholar

Portaluppi F, Smolensky MH, Touitou Y. 2010. Ethics and methods for biological rhythm research on animals and human beings. Chronobiol Int 27 (9–10):1911–1929. https://doi.org/10.3109/07420528.2010.516381
View in Google Scholar

Tabachnik M, Sheiner E, Wainstock T. 2020. The association between second to fourth digit ratio, reproductive and general health among women: findings from an Israeli pregnancy cohort. Sci Rep 10(1):6341. https://doi.org/10.1038/s41598-020-62599-3
View in Google Scholar

Wang L, Lu H, Li KK, Bai CY, Ma ZB. 2018. Digit ratio (2D:4D) in Chinese women with gastric cancer. Am J Hum Biol 30(3):e23109. https://doi.org/10.1002/ajhb.23109
View in Google Scholar

Zhang C, Dang J, Pei L, Guo M, Zhu H, Qu L, Jia F, Lu H, Huo Z. 2013. Relationship of 2D:4D finger ratio with androgen receptor CAG and GGN repeat polymorphism. Am J Hum Biol 25:101−106. https://doi.org/10.1002/ajhb.23109
View in Google Scholar

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Published

2023-09-19 — Updated on 2023-12-01

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How to Cite

Mondal, N., & Rai, R. (2023). Low 2D:4D is associated with delayed age at menarche among women of Sikkim, India. Anthropological Review, 86(3), 29–40. https://doi.org/10.18778/1898-6773.86.3.02 (Original work published September 19, 2023)

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