ACE Insertion/Deletion polymorphism (rs4646994) affects body composition in middle-aged premenopausal women with essential hypertension

Darina Falbová; Lenka Vorobeľová; Veronika Candráková Čerňanová; Radoslav Beňuš; Daniela Siváková

doi:10.2478/anre-2019-0026

Authors

Darina Falbová Department of Anthropology, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia
Lenka Vorobeľová Department of Anthropology, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia
Veronika Candráková Čerňanová Department of Anthropology, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia
Radoslav Beňuš Department of Anthropology, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia
Daniela Siváková Department of Anthropology, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia

DOI:

https://doi.org/10.2478/anre-2019-0026

Keywords:

hypertension, ACE, body composition, SNP

Abstract

This study assesses the association between angiotensin converting enzyme (ACE) I/D (rs4646994) polymorphism and body composition parameters in essential hypertension (HT) and menopausal status in Slovak women. The entire study sample comprised 575 women in two groups: 255 with HT and 320 without. Body composition parameters were measured by bioelectric impedance analyzer and ACE I/D polymorphism genotypes were detected by polymerase chain reaction. Premenopausal HT women with ACE II genotype had significantly lower body cell mass (p=0.004), extra- and intracellular water (p=0.027; p=0.004), fat free mass and muscle mass (p=0.006; P = 0.003), fat free mass index (p=0.006) and body cell mass index (p=0.003) than their ID/DD counterparts. These associations were not determined in normotensive and/or postmenopausal women. This study confirmed that ACE I/D gene polymorphism affects body composition in HT premenopausal women.

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