Mycolic Acids as Markers of Osseous Tuberculosis in the Neolithic Skeleton from Kujawy Region (Central Poland)

Beata Borowska-Strugińska; Magdalena Druszczyńska; Wiesław Lorkiewicz; Rafał Szewczyk; Elżbieta Żądzińska

doi:10.2478/anre-2014-0012

Authors

Beata Borowska-Strugińska Department of Anthroplogy, Faculty of Biology and Environmental Protection, University of Łódź, Banacha 12/16, 90-237 Łódź, Poland
Magdalena Druszczyńska Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Łódź, Poland
Wiesław Lorkiewicz Department of Anthroplogy, Faculty of Biology and Environmental Protection, University of Łódź, Poland
Rafał Szewczyk Department of Biotechnology and Industrial Microbiology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Łódź, Poland
Elżbieta Żądzińska Department of Anthroplogy, Faculty of Biology and Environmental Protection, University of Łódź, Poland

DOI:

https://doi.org/10.2478/anre-2014-0012

Keywords:

mycolic acids, paleopathology,, Neolithic

Abstract

The subject of analysis is the male skeleton from a double burial of the Globular Amphora Culture, derived from the Neolithic site at Brześć Kujawski in Kujawy region (central Poland). Within the spine of the individual advanced lesions are observed (destruction of the vertebral bodies, symptoms of the periostitis in the thoracic region) which are characteristic of skeletal tuberculosis. To check whether the observed morphological changes resulted from infection with Mycobacterium tuberculosis (M.tb), the bone material was tested positively for the presence of mycolic acids, the specific components of the cell wall of pathogenic M.tb bacilli, by mass spectrometry.

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