Odontological analysis of Polish children with unilateral cleft lip and palate

Authors

  • Piotr Sękowski Department of Anthropology, Faculty of Biology and Environmental Protection, University of Lodz, Poland
  • Elżbieta Żądzińska Department of Anthropology, Faculty of Biology and Environmental Protection, University of Lodz, Poland; Visiting research fellowship in Biological Anthropology and Comparative Anatomy Research Unit, School of Medicine, The University of Adelaide, Australia
  • Elżbieta Pawłowska Department of Orthodontics, Medical University of Lodz, Poland
  • Aneta Sitek Department of Anthropology, Faculty of Biology and Environmental Protection, University of Lodz, Poland
  • Bogusław Antoszewski Department of Plastic, Reconstructive and Aesthetic Surgery, Institute of Surgery, Medical University of Lodz, Poland

DOI:

https://doi.org/10.2478/anre-2019-0007

Keywords:

teeth, odontometry, anthropometry, oral malformations

Abstract

Tooth size, being the effect of interaction of genetic and prenatal factors, could be of importance in interpreting the multifactor causes of cleft lip/palate. Publications indicating decreased tooth parameters, no dental differences, or larger dimensions of teeth in cleft lip/palate patients. Researchers report mostly mesiodistal (MD) measurements of maxillary (affected) teeth. There is a lack of data for buccolingual (BL) diameters. Both MD and BL parameters have influence on the planning and performance of orthodontic treatment. The aim of this paper was to assess differences in mesiodistal and buccolingual tooth dimensions in Polish children with unilateral cleft lip and palate (UCLP) in comparison to patients without oral clefts. A total of 1883 permanent teeth, 1182 teeth of UCLP patients and 701 teeth of healthy participants were analyzed. Tooth diameters were performed using an orthodontic cast of dentition with a digital odontometer. The greatest anomalies were found in both maxillary canines and consisted of their reduced mesiodistal dimension and increased buccolingual dimension, resulting in a pathologically high crown shape index (BL/MD). Conclusion can be drawn that unilateral cleft lip and palate is a condition that causes morphological disturbances of varying severity in most mandibular and maxillary teeth both on the cleft and non-cleft sides.

Downloads

Download data is not yet available.

Author Biography

Aneta Sitek, Department of Anthropology, Faculty of Biology and Environmental Protection, University of Lodz, Poland

Aneta Sitek, Department of Anthropology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland

References

Akcam MO, Evirgen S, Uslu O, Memikoglu UT. 2010. Dental anomalies in individuals with cleft lip and/or palate. Eur J Orthod 32:207–13.
View in Google Scholar

Akcam MO, Toygar TU, Ozer L, Ozdemir B. 2008. Evaluation of 3-dimensional tooth crown size in cleft lip and palate patients. Am J Orthod Dentofacial Orthop 134:85–92.
View in Google Scholar

Alappat S, Zhang ZY, Chen YP. 2003. Msx homeobox gene family and craniofacial development. Cell Res 13:429–42.
View in Google Scholar

Alves LU, Pardono E, Otto PA, Mingroni Netto RC. 2015. A novel c.1037C>G (p.Ala346Gly) mutation in TP63 as cause of the ectrodactyly-ectodermal dysplasia and cleft lip/palate (EEC) syndrome. Genet Mol Biol 38:37–41.
View in Google Scholar

Antonarakis GS., Tsiouli K, Christou P. 2013. Mesiodistal tooth size in non-syndromic unilateral cleft lip and palate patients: a meta-analysis. Clin Oral Invest 17:365–77.
View in Google Scholar

Bei M, Maas R. 1998. FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development. Development 125:4325–333.
View in Google Scholar

Chung MK, Lao TT, Ting YH, Leung TY, Lau TK, Wong TW. 2013. Environmental factors in the first trimester and risk of oral-facial clefts in the offspring. Reprod Sci 20:797–803.
View in Google Scholar

Dahlberg AA. 1945. The changing dentition of man. J Am Dent Asoc. 32:676–90.
View in Google Scholar

Dewinter G, Quirynen M, Heidbüchel K, Verdonck A, Willems G, Carels C. 2003. Dental abnormalities, bone graft quality, and periodontal conditions in patients with unilateral cleft lip and palate at different phases of orthodontic treatment. Cleft Palat-Craniofac J 40:343–50.
View in Google Scholar

Fisher DM. 2005. Unilateral cleft lip repair: an anatomical subunit approximation technique. Plast Reconstr Surg 116:61–71.
View in Google Scholar

Foster TD, Lavelle CLB. 1971. The size of the dentition in complete cleft lip and palate. Clet Palate J 8:174–84.
View in Google Scholar

Gurramkonda VB, Sved AH, Murthy J, Lakkakula BV. 2015. Evidence of the involvement of the polymorphisms near MSX1 gene in non-syndromic cleft lip with or without cleft palate. Int J Pediatr Otorhinolaryngol 79:1081–84.
View in Google Scholar

Hermann NV, Zargham M, Darvann TA., Christensen IBJ, Kreiborg S. 2012. Early postnatal development of the mandibular permanent first molar in infants with isolated cleft palate. Int J Ped Dent 22:280–85.
View in Google Scholar

Johansen AM, Wilcox AJ, Lie RT, Andersen LF, Drevon CA. 2009. Maternal consumption of coffee and caffeine-containing beverages and oral clefts: a population-based case-control study in Norway. Am J Epidemiol 169:1216–22.
View in Google Scholar

Kavanagh KD, Evans AR, Jernvall J. 2007. Predicting evolutionary patterns of mammalian teeth from development. Nature 449 (7161):427–32.
View in Google Scholar

Lai MC, King NM, Wong HM. 2009 Abnormalities of maxillary anterior teeth in Chinese children with cleft lip and palate. Cleft Palate Craniofac J 46:58–64.
View in Google Scholar

Leslie EJ, Taub MA, Liu H, Steinberg KM, Koboldt DC, Zhang Q, Carlson JC et al. 2015. Identification of functional variants for cleft lip with or without cleft palate in or near PAX7, FGFR2, and NOG by targeted sequencing of GWAS loci. Am J Hum Genet 96:397–411.
View in Google Scholar

Lewis BR, Stern MR, Willmot DR. 2008. Maxillary anterior tooth size and arch dimensions in unilateral cleft lip and palate. Cleft Palate Craniofac J 45:639–46.
View in Google Scholar

Lézot F, Descroix V, Mesbah M, Hotton D, Blin C, Papgerakis P, Mauro N et al. 2002. Cross-talk between Msx/Dlx homeobox genes and vitamin D during tooth mineralization. Connect Tissue Res 43:509–14.
View in Google Scholar

Mammoto A, Torisawa YS, Tat T, Gibbs A, Derda R, Mannix R, de Bruijn M, Yung CW, Huh D, Ingber DE. 2011. Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation. Dev Cell 21:758–69.
View in Google Scholar

Margulis AV, Mitchell AA, Giloba SM, Werler MM, Mittleman MA, Glynn RJ, Hernandez-Diaz S. 2012. National Birth Defects Prevention Study: Use of topiramate in pregnancy and risk of oral clefts. Am J Obstet Gynecol 207:405. e1-7.
View in Google Scholar

Munger RG, Romitti PA, Daack-Hirsch S, Burns TL, Murray JC, Hanson J. 1996. Maternal alcohol use and risk of orofacial cleft birth defects. Teratology 54:27–33.
View in Google Scholar

Nanci A, Wazen R, Nishio C, Zalzal SF. 2008. Immunocytochemistry of matrix proteins in calcified tissues: functional biochemistry on section. Eur J Histochem 52: 201–214. Review.
View in Google Scholar

Peterka M, Müllerová Z. 1983. Tooth size in children with cleft lip and palate. Cleft Palate J 20:307–13.
View in Google Scholar

Ranta R. 1986. A review of tooth formation in children with cleft lip and palate. Am J Orthodont Dentfac Orthop 90:11–18.
View in Google Scholar

Rawashdeh MA, Bakir IF. 2007. The crown size and sexual dimorphism of permanent teeth in Jordanian cleft lip and palate patients. Cleft Palate Craniofac J 44:155–162.
View in Google Scholar

Ribeiro LL, Teixera Das Neves L, Costa B, Gomide MR. 2003. Dental abnormalities of the permanent lateral incisors and prevalence of hypodontia outside the cleft area in complete unilateral cleft lip and palate. Cleft Palate-Craniofac J 40:172–75.
View in Google Scholar

Ruhin-Poncet B, Ghoul-Mazgar S, Hotton D, Capron F, Jaafoura MH, Goubin G, Berdal A. 2009. Msx and Dlx homeogene expression in epithelial odontogenic tumors. J Histochem Cytochem 57:69–78.
View in Google Scholar

Skuladottir H, Wilcox A, McConnaughey R, Vindenes H, Lie RT. 2014. First-trimester nonsystemic corticosteroid use and the risk of oral clefts in Norway. Ann Epidemiol 24: 635–40.
View in Google Scholar

Sofaer JA. 1979. Human tooth-size asymmetry in cleft lip with or without cleft palate. Arch Oral Biol 24:141–46.
View in Google Scholar

Ulijaszek SJ, Lourie JA. 1994. Intra- and inter-observer error in anthropometric measurement. In: SJ Ulijaszek, CGN Masci-Taylor, editors. Anthropometry: the individual and the population. Cambridge: Cambridge University Press, 30–55.
View in Google Scholar

Vichi M, Franchi L. 1995. Abnormalities of the maxillary incisors in children with cleft lip and palate. J Dent Child 62:412–17.
View in Google Scholar

Walker SC, Mattick CR, Hobson RS, Steen N. 2009. Abnormal tooth size and morphology in subjects with cleft lip and/or palate in the north of England. Eu J Orth 31:68–75.
View in Google Scholar

Werner SP, Harris EF. 1989. Odontometrics of the permanent teeth in cleft lip and palate: systemic size reduction and amplified asymmetry. Cleft Palate J 26:36–41.
View in Google Scholar

Wu D, Mandal S, Choi A, Anderson A, Prochazkova M, Perry H, Gil-Da-Silva-Lopes, VL et al. 2015. DLX4 is associated with orofacial clefting and abnormal jaw development. Hum Mol Genet 24:4340–352.
View in Google Scholar

Zhao Z, Stock DW, Buchanan AV, Weiss KM. 2000. Expression of Dlx genes during the development of the murine dentition. Dev Genes Evol 210:270–75.
View in Google Scholar

Downloads

Published

2019-03-30

How to Cite

Sękowski, P., Żądzińska, E., Pawłowska, E., Sitek, A., & Antoszewski, B. (2019). Odontological analysis of Polish children with unilateral cleft lip and palate. Anthropological Review, 82(1), 91–104. https://doi.org/10.2478/anre-2019-0007

Issue

Section

Articles

Most read articles by the same author(s)

1 2 3 > >>