Association of Leu432Val (rs1056836) polymorphism of the CYP1B1 gene with lipid profile in hypertensive Slovak women

Authors

  • Darina Falbová Department of Anthropology, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia image/svg+xml
  • Lenka Vorobeľová Department of Anthropology, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia image/svg+xml
  • Veronika Candráková Čerňanová Department of Anthropology, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia image/svg+xml
  • Radoslav Beňuš Department of Anthropology, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia image/svg+xml
  • Daniela Siváková Department of Anthropology, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia image/svg+xml

DOI:

https://doi.org/10.18778/1898-6773.85.2.01

Keywords:

hypertension, Leu432Val polymorphism, menopausal status, lipids

Abstract

Leu432Val (rs1056836) polymorphism of the CYP1B1 gene was examined in relationship with lipid profile in hypertensive Slovak women according to their menopausal status. The entire study sample comprised 255 women suffering from hypertension aged from 39 to 65 years who were recruited from different localities in the western, southern, and middle parts of Slovakia. The participants provided a saliva or blood sample for DNA genotyping and a blood sample for biochemical analysis. The Leu432Val genotypes demonstrated statistically significant associations with all monitored atherogenic indices – total cholesterol-to-HDL-Cholesterol (AI1), Non-HDL-Cholesterol (AI2), LDL-Cholesterol-to-HDL-Cholesterol (AI3), and the logarithm of the ratio of plasma concentration of triglycerides to HDL-cholesterol (AIP log) in hypertensive pre/perimenopausal women. The mean values were significantly lower in women carrying the Val/Val genotype. In early postmenopausal hypertensive women the Leu432Val genotypes were statistically significant and associated with LDL-cholesterol (LDL-C) and AI2. The mean values of LDL-C and AI2 were significantly lower in women carrying the Leu/Leu genotype. In conclusion, the Leu432Val polymorphism may be associated with the atherogenic indices and LDL-C in hypertensive women.

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References

Almeida M, Soares M, Fonseca-Moutinho J, Ramalhinho AC, Breitenfeld L. 2021. Influence of Estrogenic Metabolic Pathway Genes Polymorphisms on Postmenopausal Breast Cancer Risk. Pharmaceuticals (Basel) 14(2):94.
View in Google Scholar DOI: https://doi.org/10.3390/ph14020094

Almeida S, Zandona RM, Franken N, Callegari-Jacques MS, Osorio-Wender CM, Hutz HM. 2005. Estrogen-metabolizing gene polymorphisms and lipid levels in women with different hormonal status. Pharmacogenomics J 5:346–51.
View in Google Scholar DOI: https://doi.org/10.1038/sj.tpj.6500329

Cernanova V, Dankova Z, Luptakova L, Cvicelova M, Sivakova D. 2016. The association of Asn453Ser polymorphism in CYP1B1 gene with selected somatic and biochemical variables in Slovak women of different menopause status. Menopause 23(5):577–83.
View in Google Scholar DOI: https://doi.org/10.1097/GME.0000000000000565

Coban N, Onat A, Guclu-Geyik F, Can G, Erginel-Unaltuna N. 2015. Sex- and obesity-specific association of aromatase (CYP19A1) gene variant with apolipoprotein B and hypertension. Arch Med Res 46(7):564–71.
View in Google Scholar DOI: https://doi.org/10.1016/j.arcmed.2015.09.004

Conway DE, Sakurai Y, Weiss D, Vega JD, Taylor WR, Jo H, et al. 2009. Expression of CYP1A1 and CYP1B1 in human endothelial cells: regulation by fluid shear stress. Cardiovasc Res 81(4):669–77.
View in Google Scholar DOI: https://doi.org/10.1093/cvr/cvn360

Dubey RK, Jackson EK. 2001. Estrogen-induced cardiorenal protection: potential cellular, biochemical, and molecular mechanisms. Am J Physiol Renal Physiol 280:F365–F88.
View in Google Scholar DOI: https://doi.org/10.1152/ajprenal.2001.280.3.F365

Dubey KR, Imthurn B, Barton M, Jackson KE. 2005. Vascular consequences of menopause and hormone therapy: Importance of timing of treatment and type of estrogen. Cardiovasc Res 66:295–306.
View in Google Scholar DOI: https://doi.org/10.1016/j.cardiores.2004.12.012

Duval C, Müller M, Kersten S. 2007. PPARα and dyslipidemia. Biochim Biophys Acta Mol Cell Biol Lipids 1771:961–71.
View in Google Scholar DOI: https://doi.org/10.1016/j.bbalip.2007.05.003

Elfaki I, Mir R, Almutairi MF, Abu-Duhier FM. 2018a. Cytochrome P450: polymorphisms and roles in cancer, diabetes and atherosclerosis. Asian Pac J Cancer Prev 19:2057–70.
View in Google Scholar

Elfaki I, Almutairi MF, Mir R, Khan R, Abu-Duhier FM. 2018b. Cytochrome P450 CYP1B1*2 gene and its Association with T2D in Tabuk Population, Northwestern Region of Saudi Arabia. Asian J Pharm Clin Res 11:55–59.
View in Google Scholar DOI: https://doi.org/10.22159/ajpcr.2017.v11i1.21657

Faiq MA, Dada R, Sharma R, Saluja D, Dada T. 2014. CYP1B1: A unique gene with unique characteristics. Curr Drug Metab 15(9):893–914.
View in Google Scholar DOI: https://doi.org/10.2174/1389200216666150206130058

Falbova D, Vorobelova L, Cernanova Candrakova V, Benus R, Wsolova L, Sivakova D. 2020. Association of cytochrome P450 1B1 gene polymorphisms and environmental biomarkers with hypertension in Slovak midlife women. Menopause 27(11):1287–94.
View in Google Scholar DOI: https://doi.org/10.1097/GME.0000000000001605

Fonseca MIH, da Silva IT, Ferreira SRG. 2017. Impact of menopause and diabetes on atherogenic lipid profile: Is it worth to analyse lipoprotein subfractions to assess cardiovascular risk in women? Diabetol Metab Syndr 9:22.
View in Google Scholar DOI: https://doi.org/10.1186/s13098-017-0221-5

Helmig S, Hadzaad B, Döhrel J, Schneider J. 2009. Influence of the Cyp1B1 L432V gene polymorphism and exposure to tobacco smoke on Cyp1B1 mRNA expression in human leukocytes. Drug Metab Dispos 37:1490–95.
View in Google Scholar DOI: https://doi.org/10.1124/dmd.109.027060

Helmig S, Seelinger JU, Philipp-Gehlhaar M, Döhrel J, Schneider J. 2010. Cyp1B1 mRNA expression in correlation to cotinine levels with respect to the Cyp1B1 L432V gene polymorphism. Eur J Epidemiol 25:867–73.
View in Google Scholar DOI: https://doi.org/10.1007/s10654-010-9505-x

Helmig S, Wenzel S, Maxeiner H, Schneider J. 2014. CYP1B1 mRNA inducibility due to benzo(a)pyrene is modified by the CYP1B1 L432V gene polymorphism. Mutagenesis 29:237–40.
View in Google Scholar DOI: https://doi.org/10.1093/mutage/geu010

Hlavata I, Vrana D, Smerhovsky Z, Pardini B, Naccarati A, Vodicka P, et al. 2010. Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population. Oncol Reports 24:1347–53.
View in Google Scholar DOI: https://doi.org/10.3892/or_00000992

Hu WS, Lin P, Chen CC. 2008. Association of cytochrome P450 1B1 gene expression in peripheral leukocytes with blood lipid levels in waste incinerator workers. Ann Epidemiol 18:784–91.
View in Google Scholar DOI: https://doi.org/10.1016/j.annepidem.2008.05.002

Huber CJ, Schneeberger C, Tempfer BC. 2002. Genetic modelling of the estrogen metabolism as a risk factor of hormone-dependent disorders. Maturitas 42:1–12.
View in Google Scholar DOI: https://doi.org/10.1016/S0378-5122(02)00021-X

Jinhua Q, Tetsuro Y, Nozomi T, Hiroshi N, Kenichi T. 2009. Relationship between single nucleotide polymorphisms in CYP1A1 and CYP1B1 genes and the bone mineral density and serum lipid profiles in postmenopausal Japanese women taking hormone therapy. Menopause 16:171–76.
View in Google Scholar DOI: https://doi.org/10.1097/gme.0b013e31817ed24f

Kander MC, Cui Y, Liu Z. 2017. Gender difference in oxidative stress: A new look at the mechanisms for cardiovascular diseases. J Cell Mol Med 21(5):1024–32.
View in Google Scholar DOI: https://doi.org/10.1111/jcmm.13038

Kaur-Knudsen D, Nordestgaard BG, Tybjaerg--Hansen A, Bojesen SE. 2009. CYP1B1 genotype and risk of cardiovascular disease, pulmonary disease, and cancer in 50,000 individuals. Pharmacogenet Genomics 19(9):685–94.
View in Google Scholar DOI: https://doi.org/10.1097/FPC.0b013e32833042cb

Larsen CM, Bushkofsky RJ, Gormana T, Adhami V, Mukhtar H, Wang S, et al. 2015. Cytochrome P450 1B1: An unexpected modulator of liver fatty acid homeostasis. Arch Biochem Biophys 571:21–39.
View in Google Scholar DOI: https://doi.org/10.1016/j.abb.2015.02.010

Li F, Zhu W, Gonzalez FJ. 2017. Potential role of CYP1B1 in the development and treatment of metabolic diseases. Pharmacol Ther 178:18–30.
View in Google Scholar DOI: https://doi.org/10.1016/j.pharmthera.2017.03.007

Luptakova L, Sivakova D, Sramekova D, Cvicelova M. 2012. The association of cytochrome P450 1B1 Leu432Val polymorphism with biological markers of health and menopausal symptoms in Slovak midlife women. Menopause 19:216–24.
View in Google Scholar DOI: https://doi.org/10.1097/gme.0b013e3182281b54

Malik KU, Jennings BL, Yaghini FA, Sahan-Firat S, Song CY, Estes AM, et al. 2012. Contribution of cytochrome P450 1B1 to hypertension and associated pathophysiology: A novel target for anti-hypertensive agents. Prostaglandins Other Lipid Mediat 98(3–4):69–74.
View in Google Scholar DOI: https://doi.org/10.1016/j.prostaglandins.2011.12.003

Martínez-Ramírez OC, Castro-Hernández C, Pérez-Morales R, Casas-Ávila L, de Lorena RM, Salazar-Piña A, et al. 2021. Pathological characteristics, survival, and risk of breast cancer associated with estrogen and xenobiotic metabolism polymorphisms in Mexican women with breast cancer. Cancer Causes Control 32(4):369–78.
View in Google Scholar DOI: https://doi.org/10.1007/s10552-021-01393-6

Matyjasik J, Cybulski C, Masojc B, Jakubowska A, Serrano-Fernandez P, Gorski B, et al. 2007. CYP1B1 and predisposition to breast cancer in Poland. Breast Cancer Res Treat 106:383–88.
View in Google Scholar DOI: https://doi.org/10.1007/s10549-007-9500-4

Mc Auley MT, Mooney KM. 2014. Lipid metabolism and hormonal interactions: Impact on cardiovascular disease and healthy aging. Expert Rev Endocrinol Metab 9(4):357–67.
View in Google Scholar DOI: https://doi.org/10.1586/17446651.2014.921569

Mikstacka R, Dutkiewicz Z. 2021. New Perspectives of CYP1B1 Inhibitors in the Light of Molecular Studies. Processes 9:817.
View in Google Scholar DOI: https://doi.org/10.3390/pr9050817

Mir R, Elfaki I, Jha KCh, Javid J, Babakr TA, Banu S, et al. 2021. Biological and Clinical Implications of TNF-α Promoter and CYP1B1 Gene Variations in Coronary Artery Disease Susceptibility. Cardio-vascular and Haematological Disorders 21(4):266–77.
View in Google Scholar DOI: https://doi.org/10.2174/1871529X22666211221151830

NHLBI Obesity Education Initiative Expert Panel. 2000. The practical guide: Identification, evaluation, and treatment of overweight and obesity in adults (p. 80). National Institutes of Health, National Heart, Lung, and Blood Institute, North
View in Google Scholar

American Association for the Study of Obesity; NIH Publication No. 00-4084.
View in Google Scholar

Park HY, Kim JH, Bae S, Choi YY, Park JY, Hong Y. 2015. Interaction effect of serum 25-hydroxyvitamin D levels and CYP1A1, CYP1B1 polymorphisms on blood pressure in an elderly population. J Hypertension 33(1):69–76.
View in Google Scholar DOI: https://doi.org/10.1097/HJH.0000000000000381

Patel S, Homaei A, Raju AB, Meher BR. 2018. Estrogen: The necessary evil for human health, and ways to tame it. Biomed Pharmacother 102:403–11.
View in Google Scholar DOI: https://doi.org/10.1016/j.biopha.2018.03.078

Rexrode KM, Manson JE, Lee I-M, Ridker PM, Sluss PM, Cook NR, et al. 2003. Sex hormone levels and risk of cardiovascular events in postmenopausal women. Circulation 108:1688–93.
View in Google Scholar DOI: https://doi.org/10.1161/01.CIR.0000091114.36254.F3

Shah RB, Xu W, Mraz J. 2019. Cytochrome P450 1B1: Role in health and disease and effect of nutrition on its expression. RSC Advances 9:21050–62.
View in Google Scholar DOI: https://doi.org/10.1039/C9RA03674A

Shimada T, Watanabe J, Kawajiri K, Sutter TR, Guengerich FP, Gillam EM, et al. 1999. Catalytic properties of polymorphic human cytochrome P450 1B1 variants. Carcinogenesis 20:1607–13.
View in Google Scholar DOI: https://doi.org/10.1093/carcin/20.8.1607

Sliwinski T, Sitarek P, Stetkiewicz T, Sobczuk A, Blasiak J. 2010. Polymorphism of the ERα and CYP1B1 genes in endometrial cancer in a Polish subpopulation. J Obstetrics Gynaecol Res 36:311–17.
View in Google Scholar DOI: https://doi.org/10.1111/j.1447-0756.2009.01143.x

Smerdová L, Šmerdová J, Kabátková M, Kohoutek J, Blažek D, Machala M, et al. 2014. Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway. Carcinogenesis 35:2534–43.
View in Google Scholar DOI: https://doi.org/10.1093/carcin/bgu190

Somani YB, Pawelczyk JA, de Souza MJ, Kris Etherton PM, Proctor DN. 2019. Aging women and their endothelium: Probing the relative role of estrogen on vasodilator function. Am J Physiol Heart Circ Physiol 317(2):H395–H404.
View in Google Scholar DOI: https://doi.org/10.1152/ajpheart.00430.2018

Song CY, Ghafoor K, Ghafoor HU, Khan NS, Thirunavukkarasu S, Jennings BL. 2016. Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice. Hypertension 67(1):206–13.
View in Google Scholar DOI: https://doi.org/10.1161/HYPERTENSIONAHA.115.06427

Tang YM, Green BL, Chen GF, Thompson PA, Lang NP, Shinde A, et al. 2000. Human CYP1B1 Leu432Val gene polymorphism: Ethnic distribution in African-Americans, Caucasians and Chinese; oestradiol hydroxylase activity; and distribution in prostate cancer cases and controls. Pharmacogenetics 10(9):761–766.
View in Google Scholar DOI: https://doi.org/10.1097/00008571-200012000-00001

Trubicka J, Grabowska-Kłujszo E, Suchy J, Masojć B, Serrano-Fernandez P, Kurzawski G, et al. 2010. Variant alleles of the CYP1B1 gene are associated with colorectal cancer susceptibility. BMC Cancer 10:420.
View in Google Scholar DOI: https://doi.org/10.1186/1471-2407-10-420

Wang P, Zhu B. 2017. Unique effect of 4-hydroxyestradiol and its methylation metabolites on lipid and cholesterol profiles in ovariectomized female rats. Eur J Pharmacol 800:107–17.
View in Google Scholar DOI: https://doi.org/10.1016/j.ejphar.2017.02.032

White K, Johansen AK, Nilsen M, Ciuclan L, Wallace E, Paton L, et al. 2012. Activity of the estrogen-metabolizing enzyme cytochrome P450 1B1 influences the development of pulmonary arterial hypertension. Circulation 126(9):1087–98.
View in Google Scholar DOI: https://doi.org/10.1161/CIRCULATIONAHA.111.062927

WHO. 2008. Waist circumference and waist—hip ratio: Report of a WHO expert consultation. World Health Organization (WHO). https://apps.who.int/iris/handle/ 10665/44583
View in Google Scholar

Yoon M. 2009. The role of PPARα in lipid metabolism and obesity: Focusing on the effects of estrogen on PPARα actions. Pharmacol Res 60(3):151–59.
View in Google Scholar DOI: https://doi.org/10.1016/j.phrs.2009.02.004

Zhang L, Feng L, Lou M, Deng X, Liu C, Li L. 2021. The ovarian carcinoma risk with the polymorphisms of CYP1B1 come from the positive selection. Am J Transl Res 13(5):4322–41.
View in Google Scholar

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Published

2022-07-01

How to Cite

Falbová, D., Vorobeľová, L., Candráková Čerňanová, V., Beňuš, R., & Siváková, D. (2022). Association of Leu432Val (rs1056836) polymorphism of the CYP1B1 gene with lipid profile in hypertensive Slovak women. Anthropological Review, 85(2), 1–12. https://doi.org/10.18778/1898-6773.85.2.01

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