Longitudinal and cross-sectional changes with age in selected anthropometric and physiological traits in hospitalized adults: an insight from the Polish Longitudinal Study of Aging (PLSA)
DOI:
https://doi.org/10.1515/anre-2015-0025Keywords:
aging, senescence, changes with age, longitudinal study, cross-sectional study, lifespan, longevityAbstract
Longitudinal studies of aging concerning individuals with comparable lifestyle, diet, health profile, socioeconomic status, and income remain extraordinarily rare. The purposes of our ongoing project are as follows: (i) to collect extensive data on biological and medical aspects of aging in the Polish population, (ii) to determine factors affecting the rate and course of aging, (iii) to understand how aging unfolds as a dynamic and malleable process in ontogeny, and (iv) to find novel predictors of longevity. Our investigation followed 142 physically healthy asylum inmates, including 68 males and 74 females, for at least 25 years from the age of 45 years onward. Cross-sectional assessment involved 225 inmates, including 113 males and 112 females. All the patients lived for a very long time under similar and good environmental conditions at the hospital in Cibórz, Lubuskie Province. They maintained virtually the same daily schedule and lifestyle. The rate and direction of changes with age in selected anthropometric and physiological traits were determined using ANOVA, t-test, and regression analysis. There were sex differences in the rate and pattern of age-related changes in certain characteristics such as relative weight, red blood cell count, monocyte count, thymol turbidity value, systolic blood pressure, and body temperature. Body weight, the body mass index (BMI), and total bilirubin level increased with advancing age, while body height decreased with age in both sexes. In conclusion, the aging process was associated with many regressive alterations in biological traits in both sexes but the rate and pattern of these changes depended on biological factors such as age and sex. There were only few characteristics which did not change significantly during the period under study. On the basis of comparison between the pattern of longitudinal changes with aging and the pattern of cross-sectional changes with age in the analyzed traits, we were able to predict which pattern of changes is associated with longer lifespan.
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References
Austad SN. 2012. Ageing: mixed results for dieting monkeys. Nature 489:210–11.
View in Google Scholar
Bagga A. 2013. Age changes in some linear measurements and secular trend in height in adult Indian women. Acta Biologica Szegediensis 57:51–8.
View in Google Scholar
Barbi E, Bongaarts J, Vaupel JW, editors. 2008. How long do we live? Demographic models and reflections on tempo effects. Demographic Research Monographs. Berlin: Springer.
View in Google Scholar
Bartke A. 2012. Healthy aging: is smaller better? Gerontology 58:337–43.
View in Google Scholar
Black HR, William JE. 2013. Hypertension: a companion to Braunwald’s heart disease. Philadelphia: Elsevier Saunders.
View in Google Scholar
Blagosklonny MV. 2010. Why the disposable soma theory cannot explain why women live longer and why we age. Aging 2:884–7.
View in Google Scholar
Blagosklonny MV. 2012. Answering the ultimate question “What is the proximal cause of aging?” Aging 4(12):861–77.
View in Google Scholar
Borysławski K, Chmielowiec K. 2010. Czy wysokość ciała człowieka może być predyktorem długości trwania życia? Zeszyty Naukowe Uniwersytetu Przyrodniczego we Wrocławiu 577:11–22. (in Polish)
View in Google Scholar
Borysławski K, Chmielowiec K, Chmielewski P, Chmielowiec J. 2015. Zmiany z wiekiem wybranych cech antropometrycznych, fizjologicznych i biochemicznych oraz ich związek z długością życia mężczyzn i kobiet. Monographs of Physical Anthropology Vol. 2. Published online http://www.org.up.wroc.pl/antropologia/mpa/
View in Google Scholar
(in Polish)
View in Google Scholar
Cava E, Fontana L. 2013. Will calorie restriction work in humans? Aging 5:507–14.
View in Google Scholar
Chang AM, Halter JB. 2003. Aging and insulin secretion. Am J Physiol Endocrinol Metab 284:E7–E12.
View in Google Scholar
Chmielewski P. 2015. Wysokość ciała i miesiąc urodzenia a długość życia osób zmarłych w Polsce w latach 2004–2008. Doctoral dissertation. Available at the Jagiellonian Library of the Jagiellonian University, Kraków, Poland. (in Polish)
View in Google Scholar
Chmielewski P, Borysławski K, Chmielowiec K, Chmielowiec J. 2015. Height loss with advancing age in a hospitalized population of Polish men and women: magnitude, pattern and associations with mortality. Anthropol Rev 78(2):157–68.
View in Google Scholar
Cornoni-Huntley JC, Harris TB, Everett DF, Albanes D, Micozzi MS, Miles TP, Feldman JJ. 1991. An overview of body weight of older persons, including the impact on mortality. The National Health and Nutrition Examination Survey I - Epidemiologic Follow-up Study. J Clin Epidemiol 44:743–53.
View in Google Scholar
Davey A, Lele U, Elias MF, Dore GA, Siegler IC, Johnson MA, Hausman DB, Tenover JL, Poon LW; Georgia Centenarian Study. 2012. Diabetes mellitus in centenarians. J Am Geriatr Soc 60:468–73.
View in Google Scholar
de Magelhães JP, Faragher RGA. 2008. Cell divisions and mammalian aging: integrative biology insights from genes that regulate longevity. BioEssays 30:567–78.
View in Google Scholar
Ferrucci L. 2008. The Baltimore Longitudinal Study of Aging (BLSA): a 50-year-long journey and plans for the future. J Gerontol A Biol Sci Med Sci 63:1416–9.
View in Google Scholar
Fontana L. 2009. The scientific basis of caloric restriction leading to longer life. Curr Opin Gastroenterol 25:144–50.
View in Google Scholar
Garagnani P, Giuliani C, Pirazzini C, Olivieri F, Bacalini MG, Ostan R, Mari D, Passarino G, Monti D, Bonfigli AR, Boemi M, Ceriello A, Genovese S, Sevini F,Luiselli D, Tieri P, Capri M, Salvioli S, Vijg J, Suh Y, Delledonne M, Testa R, Franceschi C. 2013. Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: a proof of principle on type 2 diabetes. Aging 5:373–85.
View in Google Scholar
Glei DA, Goldman N, Lin YH, Weinstein M. 2011. Age-related changes in biomarkers: longitudinal data from a population-based sample. Res Aging 33:312–26.
View in Google Scholar
Guarente L, Partridge L, Wallace DC, editors. 2008. Molecular biology of aging. Cold Spring Harbor Laboratory Press, 1st ed., 1–38.
View in Google Scholar
Guo SS, Zeller C, Chumlea WC, Siervogel RM. 1999. Aging, body composition, and lifestyle: the Fels Longitudinal Study. Am J Clin Nutr 70:405–11.
View in Google Scholar
He Q, Morris BJ, Grove JS, Petrovitch H, Ross W, Masaki KH, Rodriguez B, Chen R, Donlon TA, Willcox DC, Willcox BJ. 2014. Shorter men live longer: association of height with longevity and FOXO3 genotype in American men of Japanese ancestry. PLoS One 9:e94385.
View in Google Scholar
Holzenberger M, Martin-Crespo RM, Vicent D, Ruiz-Torres A. 1991. Decelerated growth and longevity in men. Arch Gerontol Geriatr 13:89–101.
View in Google Scholar
Houston M. 2009. Handbook of hypertension. Wiley-Blackwell, New York
View in Google Scholar
Johnson FB, Sinclair DA, Guarente L. 1999. Molecular biology of aging. Cell 96:291–302.
View in Google Scholar
Kemkes-Grottenthaler A. 2005. The short die young: the interrelationship between stature and longevity – evidence from skeletal remains. Am J Phys Anthropol 128:340–7.
View in Google Scholar
Kirkwood TBL. 2005. Understanding the odd science of aging. Cell 120:437–47.
View in Google Scholar
Kirkwood TBL. 2008a. Healthy old age. Nature 455:739–40.
View in Google Scholar
Kirkwood TBL. 2008b. Understanding ageing from an evolutionary perspective. J Intern Med 263(2):117–27.
View in Google Scholar
Kirkwood TBL. 2010. Why women live longer. Stress alone does not explain the longevity gap. Sci Am 303(5):34–5.
View in Google Scholar
Kirkwood TBL, Kowald A. 2012. The free-radical theory of ageing: older, wiser and still alive. Modelling positional effects of the primary targets of ROS reveals new support. BioEssays 34:692–700.
View in Google Scholar
Ljubuncic P, Reznick AZ. 2009. The evolutionary theories of aging revisited – a mini review. Gerontology 55(2):205–16.
View in Google Scholar
Longo VD, Mitteldorf J, Skulachev VP. 2005. Programmed and altruistic aging. Nat Rev Genet 6(11):866–72.
View in Google Scholar
Malinowski A, Strzałko J, editors. 1985. Antropologia. Warszawa–Poznań: Państwowe Wydawnictwo Naukowe. (in Polish)
View in Google Scholar
Martin R. 1928. Lehrbuch der Anthropologie. Erster Band: Somatologie. Jena: Fischer.
View in Google Scholar
Martin R, Saller K. 1957. Lehrbuch der Anthropologie in systematischer Darstellung. 3rd edition. Stuttgard: Fischer.
View in Google Scholar
Martin-Ruiz C, Jagger C, Kingston A, Collerton J, Catt M, Davies K, Dunn M, Hilkens C, Keavney B, Pearce SH, den Elzen WP, Talbot D, Wiley L, Bond J, Mathers JC, Eccles MP, Robinson L, James O, Kirkwood TBL, von Zglinicki T. 2011. Assessment of a large panel of candidate biomarkers of aging in the Newcastle 85+ study. Mech Ageing Dev 132:496–502.
View in Google Scholar
Mitteldorf J. 2010. Evolutionary origins of aging. In: Fahy GM, editor. The future of aging. Pathways to human life extensions. New York: Springer.
View in Google Scholar
Pérez VI, Bokov A, van Remmen H, Mele J, Ran Q, Ikeno Y, Richardson A. 2009. Is the oxidative stress theory of aging dead? Biochim Biophys Acta 1790:1005–14.
View in Google Scholar
Raina PS, Wolfson C, Kirkland SA, Griffith LE, Oremus M, Patterson C, Tuokko H, Penning M, Balion CM, Hogan D, Wister A, Payette H, Shannon H, Brazil K. 2009. The Canadian Longitudinal Study on Aging (CLSA). Can J Aging 28:221–9.
View in Google Scholar
Rolland-Cachera MF, Cole TJ, Sempé AM, Ticher J, Rossignol C, Charraud A. 1991. Body mass index variations: centiles from birth to 87 years. Eur J Clin Nutr 45:13–21.
View in Google Scholar
Rossman J. 1979. The anatomy of aging. In: Rossman J, editor. Clinical geriatrics, 2nd ednition. Philadelphia: Lippincott.
View in Google Scholar
Salaris L, Poulain M, Samaras TT. 2012. Height and survival at older ages among men born in an inland village in Sardinia (Italy), 1866–2006. Biodemography Soc Biol 58:1–13.
View in Google Scholar
Samaras TT. 2014. Evidence from eight different types of studies showing that smaller body size is related to greater longevity. Journal of Scientific Research & Reports 3(16):2150–60.
View in Google Scholar
Sanz A, Pamplona R, Barja G. 2006. Is the mitochondrial free radical theory of aging intact? Antioxid Redox Signal 8:582–99.
View in Google Scholar
Schulz R. 2006. The encyclopedia of aging. 4th edition. New York: Springer.
View in Google Scholar
Sebastiani P, Solovieff N, DeWan AT, Walsh KM, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RM, Steinberg MH, Montano M, Baldwin CT, Hoh J, Perls TT. 2012. Genetic signatures of exceptional longevity in humans. PLoS One 7:e29848.
View in Google Scholar
Shanley DP, Kirkwood TB. 2006. Caloric restriction does not enhance longevity in all species and is unlikely to do so in humans. Biogerontology 7:165–8.
View in Google Scholar
Spirduso WW, Francis KL, MacRae PG. 2005. Physical dimensions of aging. 2nd editions. Champaign: Human Kinetics.
View in Google Scholar
Sorkin JD, Muller DC, Andres R. 1999. Longitudinal change in height of men and women: Implications for interpretation of the body mass index: The Baltimore Longitudinal Study of Ageing. Am J Epidemiol 150:969–77.
View in Google Scholar
Sprott RL. 2010. Biomarkers of aging and disease: introduction and definitions. Exp Gerontol 45:2–4.
View in Google Scholar
Stout RW. 1994. Glucose tolerance and ageing. J R Soc Med 87:608–9.
View in Google Scholar
Terry DF, Wilcox MA, McCormick MA, Pennington JY, Schoenhofen EA, Andersen SL, Perls TT. 2004. Lower all-cause, cardiovascular, and cancer mortality in centenarians’ offspring. J Am Geriatr Soc 52:2074–6.
View in Google Scholar
Weindruch R, Sohal RS. 1997. Caloric intake and aging. N Engl J Med 337:986–94.
View in Google Scholar
Whelan BJ, Savva GM. 2013. Design and methodology of the Irish Longitudinal Study on Ageing. J Am Geriatr Soc 61 Suppl 2:S265–8.
View in Google Scholar
Whelton PK. 1994. Epidemiology of hypertension. Lancet 344:101–6.
View in Google Scholar
Willcox BJ, Yano K, Chen R, Willcox DC, Rodriquez BL, Masaki KH, Donlon T, Tanaka B, Curb JD. 2004. How much should we eat? The association between energy intake and mortality in a 36-year follow-up study of Japanese-American men. J Gerontol Biol Sci 59:B789–95.
View in Google Scholar
Wolański N. 2012. Rozwój biologiczny człowieka. Warszawa: Wydawnictwo Naukowe PWN. (in Polish)
View in Google Scholar
Yambe M, Tomiyama H, Yamada J, Koji Y, Motobe K, Shiina K, Yamamoto Y, Yamashina A. 2007. Arterial stiffness and progression to hypertension in japanese male subjects with high normal blood pressure. J Hypertens 25:87–93.
View in Google Scholar
Zimniak P. 2012. What is the proximal cause of aging? Front Genet 3:189.
View in Google Scholar
Zyczkowska J, Klich-Raczka A, Mossakowska M, Gasowski J, Wieczorowska-Tobis K, Grodzicki T. 2004. Blood pressure in centenarians in Poland. J Hum Hypertens 18:713–6.
View in Google Scholar
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