Adipose-derived stem cells: a review of osteogenesis differentiation

Aleksandra Skubis; Bartosz Sikora; Nikola Zmarzły; Emilia Wojdas; Urszula Mazurek

doi:10.1515/fobio-2016-0004

Authors

Aleksandra Skubis Medical University of Silesia in Katowice, Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine
Bartosz Sikora Medical University of Silesia in Katowice, Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine
Nikola Zmarzły Medical University of Silesia in Katowice, Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine
Emilia Wojdas Medical University of Silesia in Katowice, Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine
Urszula Mazurek Medical University of Silesia in Katowice, Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine

DOI:

https://doi.org/10.1515/fobio-2016-0004

Keywords:

mesenchymal stem cells, regenerative medicine, adipose tissue

Abstract

This review article provides an overview on adipose-derived stem cells (ADSCs) for implications in bone tissue regeneration. Firstly this article focuses on mesenchymal stem cells (MSCs) which are object of interest in regenerative medicine. Stem cells have unlimited potential for self-renewal and develop into various cell types. They are used for many therapies such as bone tissue regeneration. Adipose tissue is one of the main sources of mesenchymal stem cells (MSCs). Regenerative medicine intends to differentiate ADSC along specific lineage pathways to effect repair of damaged or failing organs. For further clinical applications it is necessary to understand mechanisms involved in ADSCs proliferation and differentiation. Second part of manuscript based on osteogenesis differentiation of stem cells. Bones are highly regenerative organs but there are still many problems with therapy of large bone defects. Sometimes there is necessary to make a replacement or expansion new bone tissue. Stem cells might be a good solution for this especially ADSCs which manage differentiate into osteoblast in in vitro and in vivo conditions.

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