Probiotics as a potential tool for gynecological cancers prevention and therapy suport

Olga Kuźmycz; Wiktoria Wierzbińska

doi:10.18778/1730-2366.18.12

Authors

Olga Kuźmycz University of Lodz, Faculty of Biology, Department of Molecular Microbiology, Poland https://orcid.org/0000-0002-1709-2971
Wiktoria Wierzbińska University of Lodz, Faculty of Biology, Department of Molecular Microbiology, Poland; BioMedChem Doctoral School of the University of Lodz and Lodz Institutes of the Polish Academy of Sciences, Poland

DOI:

https://doi.org/10.18778/1730-2366.18.12

Keywords:

Lactobacillus, Saccharomyces cerevisiae var. boulardii, cervical cancer, microbiome

Abstract

The human body is host to a variety of microbial species that are essential for maintaining general health. About nine percent of these microbial species inhabit the urogenital tract. It is therefore important to establish a symbiotic relationship between the host’s immune system and the microbiota in this region. Disruptions of this symbiosis can contribute to the development of pelvic inflammatory disease (PID), bacterial vaginosis (BV), vaginal candidiasis and/or even gynaecological cancers by promoting the proliferation of infectious agents. The chemotherapeutic agents currently used in cancer treatment are associated with undesirable side effects. Therefore, there is an urgent need for antitumor agents that have minimal toxicity compared to conventional treatments. Furthermore, the use of drugs to prevent or alleviate the side effects of cervical cancer treatment could significantly improve the quality of life of patients undergoing such therapy. In this review, we focus our attention on the potential efficacy of probiotics in both the prevention and therapeutic intervention of neoplasms affecting the genital tract.

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